Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy
Xia Liu, Celine L. Hartman, Lingyun Li, Carolyn J. Albert, Fusheng Si, Aiqin Gao, Lan Huang, Yangjing Zhao, Wenli Lin, Eddy C. Hsueh, Lizong Shen, Qixiang Shao, Daniel F. Hoft, David A. Ford, Guangyong Peng
Abstract
reprogrammed effector T cell lipid metabolism, prevented T cell senescence in vitro, and enhanced antitumor immunity and immunotherapy efficacy in mouse models of melanoma and breast cancer in vivo. Together, these findings identify mechanistic links between T cell senescence and regulation of lipid metabolism in the tumor microenvironment and provide a new target for tumor immunotherapy.
Topics & Concepts
ReprogrammingEffectorSenescenceCell biologyLipid metabolismImmunotherapyImmunityBiologyCell metabolismMetabolismCellImmune systemImmunologyCancer researchBiochemistryImmune cells in cancerCancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism