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When possible, report a Fisher-exact <i>P</i> value and display its underlying null randomization distribution

Marie‐Abèle Bind, Donald B. Rubin

2020Proceedings of the National Academy of Sciences61 citationsDOIOpen Access PDF

Abstract

Significance Statistical analyses of randomized experiments often rely on asymptotic P values instead of using the actual randomization procedure that led to the observed data. Fisher-exact and asymptotic P values can differ dramatically: The former should be preferred because it is calculated using the exact null randomization distribution, which, in small samples, can substantially differ from its approximating Student’s t distribution. Moreover, we may learn something scientifically interesting from examining the shape of the null randomization distribution.

Topics & Concepts

RandomizationNull (SQL)Null hypothesisNull distributionp-valueExact testMathematicsStatisticsDistribution (mathematics)Statistical hypothesis testingStatistical significanceApplied mathematicsComputer scienceRandomized controlled trialData miningMedicineTest statisticMathematical analysisSurgeryStatistical Methods and InferenceStatistical Methods in Clinical TrialsStatistical Methods and Bayesian Inference
When possible, report a Fisher-exact <i>P</i> value and display its underlying null randomization distribution | Litcius