CPEB1 Controls NRF2 Proteostasis and Ferroptosis Susceptibility in Pancreatic Cancer
Shuxia Zhang, Jingnan Huang, Zhangzhang Lan, Yanlin Xiao, Youyou Liao, Shiva Basnet, Piying Huang, Yunze Li, Jingyu Yan, Yuling Sheng, Wenwen Zhou, Qi Liu, Haoyuan Tan, Yi Jer Tan, Leyong Yuan, Lisheng Wang, Lingyun Dai, Wenyong Zhang, Changzheng Du
Abstract
. Furthermore, based on the pathological evaluation of tissue specimens from 90 PDAC patients, we established that CPEB1 is an independent prognosticator whose expression level is closely associated with clinical therapeutic outcomes in PDAC. These findings identify the role of CPEB1 as a key ferroptosis regulator and a potential prognosticator in pancreatic cancer.
Topics & Concepts
ProteostasisPancreatic cancerCancerChemistryBiologyCancer researchGeneticsRNA modifications and cancerFerroptosis and cancer prognosisCancer, Lipids, and Metabolism