Virulence Factors of the Gut Microbiome Are Associated with BMI and Metabolic Blood Parameters in Children with Obesity
Sofía M. Murga-Garrido, Ernesto Ulloa‐Pérez, Cinthya Estefhany Díaz-Benítez, Yaneth Citlalli Orbe-Orihuela, Fernanda Cornejo‐Granados, Adrián Ochoa‐Leyva, Alejandro Sánchez‐Flores, Miguel Cruz, Ana Cristina Castañeda-Márquez, Tanya Plett-Torres, Ana I. Burguete-García, Alfredo Lagunas-Martínez
Abstract
The alteration of gut microbiome composition has been commonly observed in diseases involving inflammation, such as obesity and metabolic impairment. Inflammatory host response in the gut can be a consequence of dietary driven dysbiosis. This response is conducive to blooms of particular bacterial species, adequate to survive in an inflammatory environment by means of genetical capability of utilizing alternative nutrients. Understanding the genomic and metabolic contribution of microbiota to inflammation, including virulence factor prevalence and functional potential, will contribute to identifying modifiable early life exposures and preventive strategies associated with obesity risk in childhood.