Bioorthogonal oncolytic-virus nanovesicles combined bio-immunotherapy with CAR-T cells for solid tumors
Guojun Huang, Yiran He, Xiaocong Chen, Ting Yin, Ai-Qing Ma, Lizhen Zhu, Liqi Chen, Ruijing Liang, Pengfei Zhang, Hong Pan, Lintao Cai
Abstract
CAR-T cells in tumors. Our data suggest that bioorthogonal OV nanovesicles hold great potential to overcome the limitations of CAR-T cells as monotherapies against solid tumors and, thus, drive the clinical application of combination therapy.
Topics & Concepts
Oncolytic virusBioorthogonal chemistryImmunotherapyChemistryVirusCellCancer immunotherapyVirologyCancer researchCombinatorial chemistryBiologyBiochemistryImmune systemImmunologyClick chemistryCAR-T cell therapy researchVirus-based gene therapy researchMonoclonal and Polyclonal Antibodies Research