Have spirocyclic scaffolds been properly utilized in recent drug discovery efforts?
Erica Benedetti, Laurent Micouin
Abstract
1. Spirocycles are structures in which two or more rings are linked by one common atom. Although the use of such scaffolds has been known for more than 60 years in medicinal chemistry, the increasi...
Topics & Concepts
Drug discoveryDrugComputational biologyComputer scienceNanotechnologyMedicinePharmacologyBiologyBioinformaticsMaterials scienceSynthesis and Reactivity of HeterocyclesSynthesis and Biological EvaluationChemical Synthesis and Analysis