Ketogenic diet attenuates microglia-mediated neuroinflammation by inhibiting NLRP3 inflammasome activation <i>via</i> HDAC3 inhibition to activate mitophagy in experimental autoimmune encephalomyelitis
Qianye Zhang, Mingxiao Zheng, Wei Sun, Gabriele Loers, Min Wen, Qingpeng Wang, Xuexing Zheng, Hans‐Christian Siebert, Ruiyan Zhang, Ning Zhang
Abstract
The activation of microglia is an important cause of central nervous system (CNS) inflammatory cell infiltration and inflammatory demyelination in multiple sclerosis (MS).
Topics & Concepts
Experimental autoimmune encephalomyelitisNeuroinflammationMicrogliaInflammasomeKetogenic dietMitophagyEncephalomyelitisChemistryPharmacologyMedicineNodImmunologyNeuroscienceAutophagyInflammationBiochemistryBiologyEndocrinologyEpilepsyMultiple sclerosisDiabetes mellitusApoptosisTryptophan and brain disordersDiet and metabolism studiesInflammasome and immune disorders