Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases
Scott J. Hecker, K. Raja Reddy, Olga Lomovskaya, David C. Griffith, Debora Rubio-Aparicio, Kirk Nelson, Ruslan Tsivkovski, Dongxu Sun, Mojgan Sabet, Ziad Tarazi, Jonathan Parkinson, Maxim Totrov, Serge H. Boyer, Tomasz Glinka, O.A. Pemberton, Yu Chen, Michael N. Dudley
Abstract
is a promising agent for use in combination with a β-lactam antibiotic for the treatment of a wide range of multidrug resistant Gram-negative bacterial infections, by both intravenous and oral administration.
Topics & Concepts
ChemistryAcinetobacter baumanniiEnzymeBeta-Lactamase InhibitorsEffluxBroad spectrumAntibioticsPorinSerineBiochemistryBacteriaCombinatorial chemistryEscherichia coliBacterial outer membranePseudomonas aeruginosaBiologyGeneticsGeneAntibiotic Resistance in BacteriaEnzyme Structure and FunctionBacterial Genetics and Biotechnology