Sustainable chemo-enzymatic preparation of enantiopure (<i>R</i>)-β-hydroxy-1,2,3-triazoles <i>via</i> lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents
Paola Vitale, Francesco Lavolpe, Francesca Valerio, Mariaelena Di Biase, Filippo Maria Perna, Eugenia Messina, Gennaro Agrimi, Isabella Pisano, Vito Capriati
Abstract
A chemo-enzymatic strategy for the preparation of enantiopure (<italic>R</italic>)-β-hydroxy-1,2,3-triazoles using a lactic acid bacterium as a whole-cell biocatalyst and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents is disclosed.
Topics & Concepts
Enantiopure drugBiocatalysisCycloadditionLactic acidClick chemistryBacteriaChemistryEnzymeOrganic chemistryCombinatorial chemistryReaction mechanismCatalysisEnantioselective synthesisBiologyGeneticsClick Chemistry and ApplicationsChemical Synthesis and AnalysisCyclopropane Reaction Mechanisms