CRISPR/Cas9: Role of genome editing in cancer immunotherapy
S. Vimal, Inamul Hasan Madar, Logalakshmi Thirumani, Lakshmi Thangavelu, Azhagu Madhavan Sivalingam
Abstract
• CRISPR technology revolutionizes gene editing, offering hope for curing genetic and complex diseases. • Modified cas9 enzyme enables gene activation or repression, expanding CRISPR's therapeutic applications. • CRISPR's role in cancer treatment includes innovative immunotherapies and precise gene targeting. • Experimental therapies like NY-ESO1 CRISPR method demonstrate progress in cancer-specific T cell modification. • Challenges in CRISPR delivery and safety are being addressed to unlock its full cancer treatment potential.
Topics & Concepts
CRISPRGenome editingImmunotherapyComputational biologyCancer immunotherapyBiologyGenomeGeneticsCancerGeneCRISPR and Genetic EngineeringCAR-T cell therapy researchCytomegalovirus and herpesvirus research