Electrochemical Synthesis of Carbodiimides via Metal/Oxidant-Free Oxidative Cross-Coupling of Amines and Isocyanides
Bhanwar Kumar Malviya, Pradeep Jaiswal, Ved Prakash Verma, Satpal Singh Badsara, Siddharth Sharma
Abstract
This work discloses an electrochemical oxidative cross-coupling of amines with aryl and aliphatic isocyanides. In an undivided cell, the reaction proceeds without involving any transition-metal catalyst, oxidant, or toxic reagents providing carbodiimides in good yields, thereby circumventing stoichiometric chemical oxidants, with H2 as the only byproduct. Moreover, carbodiimides were in situ converted into unsymmetrical ureas in moderate to good yields using an electricity ON–OFF strategy.
Topics & Concepts
ChemistryElectrochemistryReagentArylStoichiometryOxidative phosphorylationOxidative coupling of methaneCombinatorial chemistryCatalysisMetalOrganic chemistryElectrodeAlkylPhysical chemistryBiochemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis