<scp>LIM</scp> domain proteins in cell mechanobiology
Caitlin A. Anderson, David R. Kovar, Margaret L. Gardel, Jonathan D. Winkelman
Abstract
The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.
Topics & Concepts
Mechanosensitive channelsMechanobiologyCell biologyBiologyLIM domainCytoskeletonActinActin cytoskeletonCellGeneticsTranscription factorIon channelReceptorGeneZinc fingerCellular Mechanics and InteractionsForce Microscopy Techniques and ApplicationsCardiomyopathy and Myosin Studies