A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks
Kayla Soon, Mengyuan Li, Ruilin Wu, Angela Zhou, Negar Khosraviani, Williamson D. Turner, Joshua D. Wythe, Jason E. Fish, Sara S. Nunes
Topics & Concepts
Adherens junctionHuman brainKRASCancer researchVascular permeabilityMicrovesselPathogenesisAngiogenesisPathologyBlood vesselStroke (engine)Blood–brain barrierEndothelial stem cellArteriovenous malformationBiologyIn vitroMedicineMutationCellGeneNeuroscienceInternal medicineRadiologyCentral nervous systemGeneticsBiochemistryCadherinEngineeringMechanical engineeringVascular Malformations Diagnosis and TreatmentIntracranial Aneurysms: Treatment and ComplicationsRetinal and Macular Surgery