Interstitial flow enhances the formation, connectivity, and function of 3D brain microvascular networks generated within a microfluidic device
Max A. Winkelman, Diana Y Kim, Shravani Kakarla, Alexander Grath, Nathaniel Silvia, Guohao Dai
Abstract
We used a microfluidic device to demonstrate the advantage of generating perfused, self-assembled human brain microvascular networks in the presence of hydrostatic pressure-induced interstitial flow.
Topics & Concepts
Interstitial fluidBlood–brain barrierInterstitial spaceBiomedical engineeringChemistryCell biologyBiophysicsBasal laminaVasculogenesisOrgan-on-a-chipHuman brainIn vitroPathologyBiologyMicrofluidicsAnatomyMaterials scienceNeuroscienceNanotechnologyMedicineEndothelial stem cellBiochemistryCentral nervous systemUltrastructureBarrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus3D Printing in Biomedical Research