Methodological Development and Applications of Tryptamine-Ynamide Cyclizations in Synthesizing Core Skeletons of Indole Alkaloids
Lu Yang, Anbin Hou, Qing Jiang, Maosheng Cheng, Yongxiang Liu
Abstract
Over the past two decades, synthetic strategies for synthesizing the skeletons of various indole alkaloids based on tryptamine-ynamide have been continuously developed and applied to the total syntheses or formal total syntheses of related molecules. In this synopsis, we summarized the cyclization pathways of tryptamine-ynamide under different catalytic conditions, emphasizing the reaction mechanism and applications in the syntheses of indole alkaloids.
Topics & Concepts
TryptamineChemistryIndole testOrganic chemistryIndole alkaloidTotal synthesisStereochemistryCombinatorial chemistryBiochemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms