Litcius/Paper detail

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Jun Wang, Xufen Yu, Weida Gong, Xijuan Liu, Kwang‐Su Park, Anqi Ma, Yi‐Hsuan Tsai, Yudao Shen, Takashi Onikubo, Wen‐Chieh Pi, David F. Allison, Jing Liu, Wei‐Yi Chen, Ling Cai, Robert G. Roeder, Jian Jin, Gang Greg Wang

2022Nature Cell Biology183 citationsDOIOpen Access PDF

Topics & Concepts

EZH2TransactivationPRC2CarcinogenesisBiologyPsychological repressionCell biologyCancer researchChemistryHistoneGeneGeneticsTranscription factorGene expressionProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors Research