Small airway fibroblasts from patients with chronic obstructive pulmonary disease exhibit cellular senescence
Catherine Wrench, Jonathan Baker, Sue Monkley, Peter Fenwick, Lynne A. Murray, Louise Donnelly, Peter J. Barnes
2023American Journal of Physiology-Lung Cellular and Molecular Physiology21 citationsDOIOpen Access PDF
Abstract
Fibroblasts and senescence are thought to play key roles in the pathogenesis of small airway disease and COPD; however, the characteristics of small airway-derived fibroblasts are not well explored. In this study we isolate and enrich the senescent small airway-derived fibroblast (SAF) population from COPD lungs and explore the pathways driving this phenotype using bulk RNA-seq.
Topics & Concepts
Pulmonary diseaseSenescenceCellular senescenceAirwayMedicineFibroblastPathologyBiologyInternal medicinePhenotypeIn vitroSurgeryGeneticsGeneNeonatal Respiratory Health ResearchTelomeres, Telomerase, and SenescenceChronic Obstructive Pulmonary Disease (COPD) Research