Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?
Paul Richardson, Marian C. Bryan, Louis J. Diorazio, Fabrice Gallou, Shazia Keily, Isamir Martínez, Scott Plummer, Anthony B. Reed, Robert J. Sheppard, Jason Shields, Gail L. Wrigley, Charles S. Yeung, Álvaro Enríquez-García
Abstract
-dimethylformamide being particularly prevalent. The perspective further discusses strategies and resources available to medicinal chemists to enable the selection of more sustainable reaction media.
Topics & Concepts
ChemistryHazardous wasteSolventGreen chemistryOrganic chemistryDrugDrug discoveryMethyleneSustainabilityBiochemical engineeringCombinatorial chemistryPharmaceutical industryPharmaceutical manufacturingPhase (matter)Process (computing)Selection (genetic algorithm)ChlorideChemical industryChlorinated solventsOrganic solventProcess safetyChemistry and Chemical EngineeringChemical Reaction MechanismsInnovative Microfluidic and Catalytic Techniques Innovation