Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing <i>N</i>-Heterocyclic Scaffolds: A Review
Kibrom Mezgebe, Yadessa Melaku, Endale Mulugeta
Abstract
High Resolution Image Download MS PowerPoint Slide The incorporation of heterocyclic moieties into the standard chemical structure with a biologically active scaffold has become of crucial practice for the construction of pharmacologically potent candidates in the drug arena. Currently, numerous kinds of chalcones and their derivatives have been synthesized using the incorporation of heterocyclic scaffolds, especially chalcones bearing heterocyclic moieties that display improved efficiency and potential for drug production in pharmaceutical sectors. The current Review focuses on recent advances in the synthetic approaches and pharmacological activities such as antibacterial, antifungal, antitubercular, antioxidant, antimalarial, anticancer, anti-inflammatory, antigiardial, and antifilarial activities of chalcone derivatives incorporating N -heterocyclic moieties at either the A-ring or B-ring.