Insulin Crystals Grown in Short-Peptide Supramolecular Hydrogels Show Enhanced Thermal Stability and Slower Release Profile
Rafael Contreras-Montoya, María Arredondo‐Amador, Guillermo Escolano‐Casado, Mari C. Mañas‐Torres, Mercedes González, Mayte Conejero‐Muriel, Vaibhav Bhatia, Juan J. Díaz‐Mochon, Olga Martínez‐Augustin, Fermín Sánchez de Medina, Modesto T. López‐López, Francisco Conejero‐Lara, José A. Gavira, Luı́s Álvarez de Cienfuegos
Abstract
studies have shown that insulin does not degrade after the heat treatment. The nature of the hydrogel modifies the physicochemical properties of the crystals. Crystals grown in Fmoc-AA hydrogel are more stable and have a slower dissolution rate than crystals grown in agarose. This methodology paves the way for the development of more stable protein pharmaceuticals overcoming some of the existing limitations.
Topics & Concepts
Materials scienceSelf-healing hydrogelsThermal stabilitySupramolecular chemistryPeptideChemical engineeringInsulinSelf-assembling peptideThermalNanotechnologyBiophysicsCrystallographyPolymer chemistryCrystal structureBiochemistryInternal medicineEngineeringMedicineMeteorologyChemistryPhysicsBiologySupramolecular Self-Assembly in MaterialsRNA Interference and Gene DeliveryLipid Membrane Structure and Behavior