In vivo activation of FAP-cleavable small molecule-drug conjugates for the targeted delivery of camptothecins and tubulin poisons to the tumor microenvironment
Matilde Bocci, Aureliano Zana, Lucrezia Principi, Laura Lucaroni, Luca Prati, Ettore Gilardoni, Dario Neri, Samuele Cazzamalli, Andrea Galbiati
Topics & Concepts
In vivoFibroblast activation protein, alphaCancer researchChemistryStromal cellDrug deliveryTumor microenvironmentPharmacologyCancerMedicineBiologyInternal medicineTumor cellsOrganic chemistryBiotechnologyPeptidase Inhibition and AnalysisNeuroblastoma Research and TreatmentsUbiquitin and proteasome pathways