The Gut Microbiota of Pregnant Rats Alleviates Fetal Growth Restriction by Inhibiting the TLR9/MyD88 Pathway
Hui Tang, Hanmei Li, Dan Li, Jing Peng, Xian Zhang, Weitao Yang
Abstract
_group. FMT from FGR rats interfered with the therapeutic effects of HCQ. In conclusion, our findings suggest that TLR9 regulates the inflammatory response and gut microbiota structure in FGR, providing new insights into the pathogenesis of FGR and suggesting potential therapeutic interventions.
Topics & Concepts
BiologyEubacteriumGut floraCytokineTumor necrosis factor alphaBacteroidesImmunologyTLR9MicrobiologyGene expressionDNA methylationBiochemistryGeneGeneticsBacteriaGut microbiota and healthPreterm Birth and ChorioamnionitisImmune Response and Inflammation