Notch signaling regulates a metabolic switch through inhibiting PGC-1α and mitochondrial biogenesis in dedifferentiated liposarcoma
Pei-Chieh Tien, Xiyue Chen, Bennett D. Elzey, Raphael E. Pollock, Shihuan Kuang
Topics & Concepts
BiologyMitochondrial biogenesisWarburg effectMitochondrionCell biologyCancer researchNotch signaling pathwayCoactivatorMitophagyPeroxisome proliferator-activated receptorCarcinogenesisRegulatorSignal transductionGeneticsCancer cellReceptorAutophagyCancerApoptosisTranscription factorGeneCancer-related molecular mechanisms researchRNA Research and SplicingMicroRNA in disease regulation