Free‐radical Initialized Cyclization of 2‐(3‐Arylpropioloyl)benzaldehydes with Toluene Derivatives: Access to Benzylated 1,4‐Naphthoquinones via Copper‐Catalyzed Cascade Reaction
Bingbin Zhu, Hang Han, Weike Su, Chuanming Yu, Xinpeng Jiang
Abstract
Abstract A copper‐catalyzed cyclization reaction of 2‐(3‐arylpropioloyl)benzaldehydes was developed, leading to benzylated 1,4‐naphthoquinones via radical‐triggered cascade cyclization. This example of an acylbenzylation involving internal alkynes could be carried out with a broad substrate scope and wide functional group tolerance. magnified image
Topics & Concepts
ChemistryCascadeTolueneCatalysisRadical cyclizationCopperSubstrate (aquarium)Cascade reactionCombinatorial chemistryFunctional groupOrganic chemistryOceanographyGeologyChromatographyPolymerCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsBioactive Compounds and Antitumor Agents