A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis
Jiaojiao Fan, Xinyue Xu, Yuting Li, Lingge Zhang, Mengqiu Miao, Yujia Niu, Yue Zhang, Aihua Zhang, Zhanjun Jia, Mengqiu Wu
Topics & Concepts
CisplatinNephrotoxicityReactive oxygen speciesOxidative stressMitochondrionChemistryMitochondrial ROSPharmacologyCancer researchProgrammed cell deathAcute kidney injuryCell biologyBiochemistryApoptosisChemotherapyBiologyToxicityMedicineInternal medicineOrganic chemistryGeneticsDrug Transport and Resistance MechanismsFerroptosis and cancer prognosisMicroRNA in disease regulation