Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing
Ran An, Yuncheng Man, Shamreen Iram, Erdem Kucukal, Muhammad Noman Hasan, Yuning Huang, Utku Goreke, Allison Bode, Ailis Hill, Kevin Cheng, Zoe Sekyonda, Sanjay Ahuja, Jane A. Little, Michael Hinczewski, Umut A. Gürkan
Abstract
) from Bland-Altman analysis on the test set. Resultant anemia detection is achieved with 100% sensitivity and 92.3% specificity. With the same tests, subjects with sickle cell disease were identified with 100% sensitivity and specificity. Overall, the presented platform enabled, for the first time, integrated anemia detection and hemoglobin variant identification using a single point-of-care test.
Topics & Concepts
Point-of-care testingHemoglobinAnemiaPoint of careIdentification (biology)Hemoglobin variantsComputer scienceChromatographyMedicineComputational biologyChemistryBiologyImmunologyInternal medicinePathologyBotanyBiosensors and Analytical DetectionAdvanced biosensing and bioanalysis techniquesSARS-CoV-2 detection and testing