Synthesis of broad-specificity activity-based probes for <i>exo</i>-β-mannosidases
Nicholas G. S. McGregor, C.J. Kuo, Thomas J. M. Beenakker, Chun-Sing Wong, Wendy A. Offen, Zachary Armstrong, Bogdan I. Florea, Jeroen D. C. Codée, Herman S. Overkleeft, Johannes M. F. G. Aerts, G.J. Davies
Abstract
New cyclophellitol-derived probes covalently label β-mannosidases, enabling the detection of diverse mannosidases via activity-based protein profiling.
Topics & Concepts
ChemistryStereochemistryCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchLysosomal Storage Disorders Research