Low Susceptibility of Pigs against Experimental Infection with HPAI Virus H5N1 Clade 2.3.4.4b
Annika Graaf, Ronja Piesche, Julia Sehl‐Ewert, Christian Grund, Anne Pohlmann, Martin Beer, Timm Harder
Abstract
We found that nasal and alimentary experimental exposure of pigs to highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b was associated with marginal viral replication, without inducing any clinical manifestation or pathological changes. Only 1 of 8 pigs seroconverted, pointing to high resistance of pigs to clade 2.3.4.4b infection.
Topics & Concepts
CladeInfluenza A virus subtype H5N1VirologyBiologyVirusHighly pathogenicInfluenza A virusViral replicationGenePhylogeneticsGeneticsInfluenza Virus Research StudiesAnimal Disease Management and EpidemiologyAnimal Virus Infections Studies