On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine
Feng‐Peng Wang, Chao Ruo-bing
Abstract
This review summarizes the process of the discovery, research, and development of a cardioactive component, mesaconine, from the lateral roots of Aconitum carmichaelii ("Fu Zi"). To date, pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency, low toxicity, and a new mechanism.
Topics & Concepts
Plant biochemistryDrug discoveryPharmacologyMedicinePotencyTraditional medicineChemistryBiologyBioinformaticsBiochemistryIn vitroGenePlant-based Medicinal ResearchBioactive Natural Diterpenoids ResearchAlkaloids: synthesis and pharmacology