Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis
Wanghao Chen, Hong Wang, Zhihan Zhu, Jia Feng, Lukui Chen
Abstract
, while silencing of SIRT1 reversed the protective effects of exosomal circSHOC2 on hypoxic cerebral neurons. Taken together, our findings indicate that circSHOC2 in IPAS-EXOs suppressed neuronal apoptosis and ameliorated neuronal damage by regulating autophagy and acting on the miR-7670-3p/SIRT1 axis, which might contribute to a therapeutic strategy for ischemic stroke treatment.
Topics & Concepts
NeuroprotectionAutophagyMicrovesiclesChemistryGene silencingCell biologySmall interfering RNAExosomeApoptosisDownregulation and upregulationPharmacologyTransfectionBiologymicroRNABiochemistryGeneCircular RNAs in diseasesExtracellular vesicles in diseaseMicroRNA in disease regulation