Rapid Polysorbate 80 Degradation by Liver Carboxylesterase in a Monoclonal Antibody Formulated Drug Substance at Early Stage Development
Sisi Zhang, Hui Xiao, Rosalynn C. Molden, Haibo Qiu, Ning Li
Topics & Concepts
Serine hydrolaseCarboxylesteraseChemistryDrugMonoclonal antibodyBiochemistryEsteraseChromatographyMolecular biologyAntibodyEnzymeSerinePharmacologyBiologyImmunologyProtein purification and stabilityEffects and risks of endocrine disrupting chemicalsEnzyme Catalysis and Immobilization