TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments
Yuan-Li Tsai, Marcel Arias-Badia, Theresa A. Kadlecek, Yee May Lwin, Aahir Srinath, Neel H. Shah, Zhi-En Wang, Diane L. Barber, John Kuriyan, Lawrence Fong, Arthur Weiss
Topics & Concepts
T-cell receptorDephosphorylationBiologyUbiquitin ligaseCell biologyUbiquitinAutocrine signallingT cellPhosphorylationPhosphataseJurkat cellsSignal transductionBiochemistryReceptorImmune systemImmunologyGeneUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyProtein Tyrosine Phosphatases