Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue
Inna Gertsenshteyn, Mihai Giurcanu, Peter Vaupel, Howard J. Halpern
Abstract
Abstract Measuring molecular oxygen levels in vivo has been the cornerstone of understanding the effects of hypoxia in normal tissues and malignant tumors. Here we discuss the advances in a variety of partial pressure of oxygen ( ) measurements and imaging techniques and relevant oxygen thresholds. A focus on electron paramagnetic resonance (EPR) imaging shows the validation of treating hypoxic tumours with a threshold of ≤ 10 Torr, and demonstrates utility for in vivo oxygen imaging, as well as its current and future role in cancer studies. image
Topics & Concepts
Electron paramagnetic resonanceOxygenMagnetic resonance imagingIn vivoNuclear magnetic resonanceTorrChemistryPreclinical imagingMaterials scienceMedicineBiologyRadiologyPhysicsBiotechnologyOrganic chemistryThermodynamicsElectron Spin Resonance StudiesAdvanced MRI Techniques and ApplicationsLanthanide and Transition Metal Complexes