Massively parallel characterization of CYP2C9 variant enzyme activity and abundance
Clara J. Amorosi, Melissa A. Chiasson, Matthew G. McDonald, Lai Hong Wong, Katherine A. Sitko, Gabriel Boyle, John P. Kowalski, Allan E. Rettie, Douglas M. Fowler, Maitreya J. Dunham
Topics & Concepts
Missense mutationCYP2C9Massive parallel sequencingCytochrome P450BiologyComputational biologyEnzymeGeneticsMutationBiochemistryGeneDNA sequencingPharmacogenetics and Drug MetabolismStatistical Methods in Clinical TrialsComputational Drug Discovery Methods