Tripterygium wilfordii derivative celastrol, a YAP inhibitor, has antifibrotic effects in systemic sclerosis
Pratyusha Chitturi, Shiwen Xu, Bahja Ahmed Abdi, John Nguyen, David E. Carter, Sarthak Sinha, Rohit Arora, Jeff Biernaskie, Richard Stratton, Andrew Leask
Topics & Concepts
CelastrolFibrosisCTGFMedicineCancer researchBleomycinDermal fibroblastTransforming growth factorFibroblastPathologyBiologyGrowth factorEndocrinologyInternal medicineCell cultureApoptosisReceptorChemotherapyBiochemistryGeneticsSystemic Sclerosis and Related DiseasesHippo pathway signaling and YAP/TAZConnective Tissue Growth Factor Research