Paneth Cells Protect against Acute Pancreatitis via Modulating Gut Microbiota Dysbiosis
Yang Fu, Qixiang Mei, Nuoming Yin, Zehua Huang, Baiwen Li, Shengzheng Luo, Binqiang Xu, Junjie Fan, Chunlan Huang, Yue Zeng
Abstract
research showed that the severity of AP was exacerbated by the long-term dysfunction of Paneth cells, which was associated with gut microbiota disorder. Restoring part of Paneth cell functions through lysozyme supplementation alleviated the severity of AP and gut microbiota dysbiosis. This study provides novel insight into the link of pancreas-gut interactions in the pathogenesis of AP, providing a new direction for the clinical treatment of intestinal complications during AP.
Topics & Concepts
DysbiosisGut floraMicrobiologyPancreatitisAcute pancreatitisChemistryBiologyMedicineImmunologyInternal medicinePancreatitis Pathology and TreatmentGut microbiota and healthDiet and metabolism studies