A Decade-Long Evaluation of Neonatal Septicaemic Escherichia coli: Clonal Lineages, Genomes, and New Delhi Metallo-Beta-Lactamase Variants
Amrita Bhattacharjee, Kirsty Sands, Shravani Mitra, Ritojeet Basu, Bijan Saha, Olivier Clermont, Shanta Dutta, Sulagna Basu
Abstract
Multidrug-resistant and virulent ExPEC causing sepsis in neonates is a challenge to neonatal health. The presence of enzymes, such as carbapenemases ( bla NDM ) that hydrolyze most β-lactam antibiotic compounds, result in difficulties when treating neonates. The characterization of ExPECs collected over 10 years showed that 44% of ExPECs were carbapenem-resistant, possessing transmissible bla NDM genes.
Topics & Concepts
BiologySubcladeEscherichia coliVirulenceMicrobiologyGenomeGeneticsPlasmidResistomeContext (archaeology)CarbapenemMobile genetic elementsAntibioticsPhylogenetic treeGeneCladePaleontologyAntibiotic Resistance in BacteriaEscherichia coli research studiesBacterial Identification and Susceptibility Testing