Enhancing the biological activity of polyoxometalate–peptide nano-fibrils by spacer design
Valeria Tagliavini, Claudia Honisch, Simona Serratì, Amalia Azzariti, Marcella Bonchio, Paolo Ruzza, Mauro Carraro
Abstract
Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson-Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability.
Topics & Concepts
PolyoxometalatePeptideNano-FibrilNanotechnologyAmyloid fibrilCollagen fibrilChemistryMaterials scienceBiophysicsBiochemistryComposite materialBiologyMedicineCatalysisAmyloid βDiseasePathologyPolyoxometalates: Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisMetal-Organic Frameworks: Synthesis and Applications