Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma
Xiaofeng Ding, Chen Zhang, Huajian Chen, Minghua Ren, Xiaodong Liu
Abstract
Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to find sensitive and specific molecular targets. In this work, we reveal the relationship between the expression of cathepsins and radioresistance in GBM. We analyzed cathepsins (cathepsin B, cathepsin D, cathepsin L, and cathepsin Z/X), which are highly associated with the radioresistance of GBM by regulating different types of cell death. Cathepsins could be potential targets for GBM treatment.
Topics & Concepts
RadioresistanceCathepsinCancer researchCathepsin SProgrammed cell deathCathepsin LCathepsin BBiologyCell cultureEnzymeApoptosisBiochemistryGeneticsCalpain Protease Function and RegulationCancer-related molecular mechanisms researchRNA Research and Splicing