Synthesis of 1,2-Disubstituted Adamantane Derivatives by Construction of the Adamantane Framework
Matthew H. Todd, Radim Hrdina
Abstract
This review summarizes achievements in the synthesis of 1,2-disubstituted adamantane derivatives by the construction of the tricyclic framework either by total synthesis or by ring expansion/contraction reactions of corresponding adamantane homologues. It is intended to complement reviews focusing on the preparation of 1,2-disubstituted derivatives by C-H functionalization methods.
Topics & Concepts
AdamantaneChemistryRing (chemistry)Surface modificationCombinatorial chemistryComplement (music)StereochemistryOrganic chemistryBiochemistryPhysical chemistryGeneComplementationPhenotypeEicosanoids and Hypertension PharmacologyOrganic Chemistry Cycloaddition ReactionsOxidative Organic Chemistry Reactions