Nonproteinuric diabetic kidney disease
Masayuki Yamanouchi, Kengo Furuichi, Junichi Hoshino, Yoshifumi Ubara, Takashi Wada
Abstract
Proteinuria has been considered to be the hallmark of diabetic kidney disease and to precede renal function loss. However, it has become clear that a substantial proportion of patients either with type 1 diabetes or type 2 diabetes have renal function loss without proteinuria, known as nonproteinuric diabetic kidney disease. Despite increasing recognition of the prevalence of nonproteinuric diabetic kidney disease, data on this phenotype of diabetic kidney disease is sparse. This review describes ever known clinical and pathological manifestations, renal prognosis, and mortality in patient with nonproteinuric diabetic kidney disease.
Topics & Concepts
MedicineNephrologyProteinuriaDiabetes mellitusDiseaseRenal functionKidneyKidney diseaseInternal medicineType 2 diabetesPathologicalUrologyEndocrinologyChronic Kidney Disease and DiabetesRenal Diseases and GlomerulopathiesDialysis and Renal Disease Management