High methylation levels of histone H3 lysine 9 associated with activation of hypoxia-inducible factor 1α (HIF-1α) predict patients’ worse prognosis in human hepatocellular carcinomas
Yanyan Qian, Yiping Li, Chuqian Zheng, Tianyu Lu, Rui Sun, Yuhang Mao, Shenling Yu, Hong Fan, Zhihong Zhang
Topics & Concepts
Histone H3HistoneEZH2Histone methyltransferaseHistone methylationMethylationBiologyCancer researchLysineHypoxia-inducible factorsEpigeneticsHypoxia (environmental)Molecular biologyChemistryDNA methylationGene expressionBiochemistryOxygenGeneAmino acidOrganic chemistryEpigenetics and DNA MethylationCancer, Hypoxia, and MetabolismRNA modifications and cancer