Carbamazepine Ozonation Byproducts: Toxicity in Zebrafish (<i>Danio rerio</i>) Embryos and Chemical Stability
Johannes Pohl, Oksana Golovko, Gunnar Carlsson, Johan Eriksson, Anders Glynn, Stefan Örn, Jana M. Weiss
Abstract
) embryos. BQM and BQD were isolated from the ozonated solution as they were not commercially available. The study confirmed that the OBP mixture caused embryotoxic responses comparable to that of ozonated CBZ. Individual compound embryotoxicity assessment further revealed that BQM and BQD were the drivers of embryotoxicity. OBP chemical stability in ozonated CBZ water solution during 2 week dark storage at 22 °C was also assessed. The OBP concentrations remained over time, except for BQD which decreased by 94%. Meanwhile, ozonated CBZ persistently induced embryotoxicity over 2 week storage, potentially illustrating environmental concern.
Topics & Concepts
ChemistryToxicityEffluentCarbamazepineAcute toxicityTraditional medicineToxicologyPharmacologyBiologyOrganic chemistryMedicineNeuroscienceEpilepsyEngineeringEnvironmental engineeringPharmaceutical and Antibiotic Environmental ImpactsPharmacological Effects and Toxicity StudiesAntibiotics Pharmacokinetics and Efficacy