Hepatoprotective effect of total flavonoids from <i>Glycyrrhiza uralensis</i> Fisch in liver injury mice
Sanhu Gou, Miao He, Beibei Li, Ningyi Zhu, Jingman Ni
Abstract
and their total content in LTF were more than 60%. Hepatoprotective effects of LTF were investigated in three kinds of hepatic injury mice model induced by high-fat emulsion, Chinese liquor and tetrachloromethane. Serum ALT, AST and ALP levels and hepatic MDA, TG, cholesterol, and hydroxyproline of hepatic injury mice were reduced by LTF. Simultaneously, hepatic SOD and glutathione were increased by LTF. These results suggested that LTF can repair liver tissue and reduce hepatic injury via alleviating inflammation, improving antioxidant enzyme activity and reducing oxidative stress in liver tissue and it may be a valuable natural source of hepatoprotective activity.
Topics & Concepts
Glycyrrhiza uralensisChemistryLiver injuryAntioxidantHydroxyprolineGlycyrrhizaGlutathioneOxidative stressPharmacologyTraditional medicineBiochemistryEnzymeMedicinePathologyAlternative medicinePharmacological Effects of Natural CompoundsDrug-Induced Hepatotoxicity and ProtectionLiver Disease Diagnosis and Treatment