A New Potential Resource in the Fight against Candida auris: the <i>Cinnamomum zeylanicum</i> Essential Oil in Synergy with Antifungal Drug
Maura Di Vito, Stefanıa Garzoli, Roberto Rosato, Melinda Mariotti, Jacopo Gervasoni, Lavinia Santucci, Elisa Ovidi, Margherita Cacaci, G. Lombarini, Riccardo Torelli, Andrea Urbani, Maurizio Sanguinetti, Francesca Bugli
Abstract
This study highlights how small doses of CZ-EO are able to inhibit the secretion of fluconazole and promote its accumulation in the fungal cell. In this manner, the drug is able to exert its pharmacological effects bypassing the resistance of the yeast. If further studies will confirm this synergy, it will be possible to develop new therapeutic formulations active in the fight against C. auris resistances.
Topics & Concepts
Candida aurisFluconazoleCinnamomum zeylanicumEssential oilCinnamaldehydeCinnamomumAntifungalPharmacologyMicrobiologyTraditional medicineChemistryBiologyMedicineFood scienceBiochemistryTraditional Chinese medicinePathologyAlternative medicineCatalysisCassiaAntifungal resistance and susceptibilityEssential Oils and Antimicrobial ActivityPlant chemical constituents analysis