Safety and efficacy of CAR T cells in a patient with lymphoma and a coexisting autoimmune neuropathy
Khushali Jhaveri, Ilana Schlam, Noa G. Holtzman, Monica Peravali, Perry K. Richardson, Saurabh Dahiya, Vera Malkovska, Aaron P. Rapoport
Abstract
Key Points CAR T-cell therapy was safe and effective in a DLBCL patient with coexisting autoimmune neuropathy. CD19 CAR T-cell therapy may control refractory autoantibodies and monoclonal gammopathies.
Topics & Concepts
MedicineCAR T-cell therapyCD19LymphomaAutoantibodyMonoclonalPeripheral neuropathyImmunologyRefractory (planetary science)Monoclonal antibodyInternal medicineOncologyImmunotherapyAntibodyChimeric antigen receptorEndocrinologyDiabetes mellitusBiologyImmune systemAstrobiologyCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsVirus-based gene therapy research