Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: The new molecular mechanism of ibudilast and its implication for neuroprotective therapy
Yanming Chen, Hongfeng Wang, Zheng Ying, Qingzhi Gao
Topics & Concepts
TFEBAutophagymTORC1Cell biologyAmyotrophic lateral sclerosisSOD1NeuroprotectionPharmacologyChemistryCancer researchBiologyMedicineDiseaseSignal transductionPI3K/AKT/mTOR pathwayBiochemistryPathologyApoptosisAmyotrophic Lateral Sclerosis ResearchCholinesterase and Neurodegenerative DiseasesParkinson's Disease Mechanisms and Treatments