Synthesis of Seleno Oxindoles <i>via</i> Electrochemical Cyclization of <i>N</i>‐arylacrylamides with Diorganyl Diselenides
Xin‐Yu Wang, Yuan‐Fang Zhong, Zu‐Yu Mo, Shi‐Hong Wu, Yanli Xü, Haitao Tang, Ying‐Ming Pan
Abstract
Abstract The tandem cyclization of acrylamide with diselenides facilitated by electrochemical oxidation was successfully developed. This strategy provided an environmentally friendly method for the construction of C−Se bond. A series of seleno oxindoles with pharmacological activity were obtained by using this well‐designed tandem cyclization strategy. The in vitro antitumor activity of the compounds was also screened through MTT assay. Results showed that the seleno oxindoles exhibited better antitumor activity than other oxindole derivatives. magnified image
Topics & Concepts
ChemistryTandemOxindoleCombinatorial chemistryElectrochemistryOrganic chemistryElectrodeCatalysisComposite materialPhysical chemistryMaterials scienceSulfur-Based Synthesis TechniquesOrganoselenium and organotellurium chemistryRadical Photochemical Reactions