A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles
Víctor García‐Vázquez, Larry Hoteite, Christopher P. Lakeland, David Watson, Joseph P. A. Harrity
Abstract
3-Fluoro- and trifluoromethylthio-piperidines represent important building blocks for discovery chemistry. We report a simple and efficient method to access analogs of these compounds that are armed with rich functionality allowing them to be chemoselectively derivatized with high diastereocontrol.
Topics & Concepts
AnnulationChemistryCatalysisCombinatorial chemistrySimple (philosophy)Organic chemistryPhilosophyEpistemologyFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms