Associations Between Antiretroviral Regimen and Changes in Blood Pressure: Results From the D2EFT Study
Phyo Pyae Nyein, Kathy Petoumenos, Margaret Borok, Nnakelu Eriobu, Nagalingeswaran Kumarasamy, Anchalee Avihingsanon, Iskandar Azwa, Sounkalo Dao, Mohamed Cissé, Nila J. Dharan, Josh Hanson, Gail Matthews
Abstract
In this randomized controlled study, individuals taking dolutegravir+darunavir/ritonavir had greater increases in systolic and diastolic blood pressure than those taking 2 nucleoside reverse-transcriptase inhibitors+darunavir/ritonavir at week-48. The difference remained significant after controlling for confounding factors, including weight gain.
Topics & Concepts
MedicineRegimenBlood pressureHuman immunodeficiency virus (HIV)Internal medicineImmunologyHIV-related health complications and treatmentsBlood Pressure and Hypertension StudiesNeurological Complications and Syndromes